Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules

The Huntington’s disease (HD) mutation leads to a complex process of Huntingtin (Htt) aggregation into multimeric species that eventually form visible inclusions in cytoplasm, nuclei and neuronal processes. One hypothesis is that smaller, soluble forms of amyloid proteins confer toxic effects and co...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Sontag, Emily Mitchell, Lotz, Gregor P., Yang, Guocheng, Sontag, Christopher J., Cummings, Brian J., Glabe, Charles G., Muchowski, Paul J., Thompson, Leslie Michels
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2012
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786168/
https://ncbi.nlm.nih.gov/pubmed/24086178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-2012-129004
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