Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules

The Huntington’s disease (HD) mutation leads to a complex process of Huntingtin (Htt) aggregation into multimeric species that eventually form visible inclusions in cytoplasm, nuclei and neuronal processes. One hypothesis is that smaller, soluble forms of amyloid proteins confer toxic effects and co...

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Hauptverfasser: Sontag, Emily Mitchell, Lotz, Gregor P., Yang, Guocheng, Sontag, Christopher J., Cummings, Brian J., Glabe, Charles G., Muchowski, Paul J., Thompson, Leslie Michels
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786168/
https://ncbi.nlm.nih.gov/pubmed/24086178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-2012-129004
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