Regulation of MicroRNA Expression by Rifampin in Human Hepatocytes

Rifampin causes drug interactions by altering hepatic drug metabolism. Because microRNAs (miRNAs) have been shown to regulate genes involved in drug metabolism, we determined the effect of rifampin on the expression of hepatic miRNAs. Primary human hepatocytes from seven subjects were treated with r...

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Hlavní autoři: Ramamoorthy, Anuradha, Liu, Yunlong, Philips, Santosh, Desta, Zeruesenay, Lin, Hai, Goswami, Chirayu, Gaedigk, Andrea, Li, Lang, Flockhart, David A., Skaar, Todd C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2013
Témata:
Special Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781376/
https://ncbi.nlm.nih.gov/pubmed/23935064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052886
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