Regulation of MicroRNA Expression by Rifampin in Human Hepatocytes

Rifampin causes drug interactions by altering hepatic drug metabolism. Because microRNAs (miRNAs) have been shown to regulate genes involved in drug metabolism, we determined the effect of rifampin on the expression of hepatic miRNAs. Primary human hepatocytes from seven subjects were treated with r...

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Detalhes bibliográficos
Main Authors: Ramamoorthy, Anuradha, Liu, Yunlong, Philips, Santosh, Desta, Zeruesenay, Lin, Hai, Goswami, Chirayu, Gaedigk, Andrea, Li, Lang, Flockhart, David A., Skaar, Todd C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Special Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781376/
https://ncbi.nlm.nih.gov/pubmed/23935064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052886
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