Rifampin modulation of xeno‐ and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes

Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno‐ and endo‐biotic metabolism. Primary human hepatocytes from 7 subjects were t...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Gufford, Brandon T., Robarge, Jason D., Eadon, Michael T., Gao, Hongyu, Lin, Hai, Liu, Yunlong, Desta, Zeruesenay, Skaar, Todd C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869567/
https://ncbi.nlm.nih.gov/pubmed/29610665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.386
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