Variants in the CYP2B6 3′UTR alter in vitro and in vivo CYP2B6 activity: potential role of microRNAs

CYP2B6*6 and CYP2B6*18 are the most clinically important variants causing reduced CYP2B6 protein expression and activity. However, these variants do not account for all variability in CYP2B6 activity. Emerging evidence has shown that genetic variants in the 3′UTR may explain variable drug response b...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Burgess, Kimberly S., Ipe, Joseph, Swart, Marelize, Metzger, Ingrid F., Lu, Jessica, Gufford, Brandon T., Thong, Nancy, Desta, Zeruesenay, Gaedigk, Roger, Pearce, Robin E., Gaedigk, Andrea, Liu, Yunlong, Skaar, Todd C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871545/
https://ncbi.nlm.nih.gov/pubmed/28960269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.892
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