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Effects of the CYP2B6*6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo

The mechanism by which CYP2B6*6 allele alters drug metabolism in vitro and in vivo is not fully understood. To test the hypothesis that altered substrate binding and/or catalytic properties contribute to its functional consequences, efavirenz 8-hydroxylation and bupropion 4-hydroxylation were determ...

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Bibliografske podrobnosti
Main Authors: Xu, Cong, Ogburn, Evan T., Guo, Yingying, Desta, Zeruesenay
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310426/
https://ncbi.nlm.nih.gov/pubmed/22232427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.042416
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