CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling

Efavirenz is mainly cleared by CYP2B6. The CYP2B6*6 allele is associated with lower efavirenz clearance. Efavirenz clearance was predictable using in vitro data for carriers of the CYP2B6*1/*1 genotype, but the prediction in carriers of the CYP2B6*6 allele was poor. To test the hypothesis that incor...

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Detalhes bibliográficos
Main Authors: Xu, Cong, Quinney, Sara K., Guo, Yingying, Hall, Stephen D., Li, Lang, Desta, Zeruesenay
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834132/
https://ncbi.nlm.nih.gov/pubmed/23846872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.051755
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