Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype-dependent

Efavirenz increases CYP2C19- and CYP3A-mediated omeprazole metabolism. We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz. Healthy subjects (n=57) were administered a single 20mg oral dose of omeprazole with a single...

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Autores principales: Michaud, Veronique, Kreutz, Yvonne, Skaar, Todd, Ogburn, Evan, Thong, Nancy, Flockhart, David A., Desta, Zeruesenay
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740059/
https://ncbi.nlm.nih.gov/pubmed/23629159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2013.17
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