Wird geladen...

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype-dependent

Efavirenz increases CYP2C19- and CYP3A-mediated omeprazole metabolism. We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz. Healthy subjects (n=57) were administered a single 20mg oral dose of omeprazole with a single...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Michaud, Veronique, Kreutz, Yvonne, Skaar, Todd, Ogburn, Evan, Thong, Nancy, Flockhart, David A., Desta, Zeruesenay
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740059/
https://ncbi.nlm.nih.gov/pubmed/23629159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2013.17
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!