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Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype-dependent
Efavirenz increases CYP2C19- and CYP3A-mediated omeprazole metabolism. We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz. Healthy subjects (n=57) were administered a single 20mg oral dose of omeprazole with a single...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740059/ https://ncbi.nlm.nih.gov/pubmed/23629159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2013.17 |
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