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In Silico and In Vitro Identification of MicroRNAs That Regulate Hepatic Nuclear Factor 4α Expression

Hepatic nuclear factor 4α (HNF4A) is a nuclear transcription factor that regulates the expression of many genes involved in drug disposition. To identify additional molecular mechanisms that regulate HNF4A, we identified microRNAs (miRNAs) that target HNF4A expression. In silico analyses suggested t...

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Detalhes bibliográficos
Main Authors: Ramamoorthy, Anuradha, Li, Lang, Gaedigk, Andrea, Bradford, L. DiAnne, Benson, Eric A., Flockhart, David A., Skaar, Todd C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310421/
https://ncbi.nlm.nih.gov/pubmed/22232426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.040329
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