Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain

[Image: see text] A strategy for introducing structural diversity into polyketides by exploiting the promiscuity of an in-line methyltransferase domain in a multidomain polyketide synthase in reported. In vitro investigations using the highly-reducing fungal polyketide synthase CazF revealed that it...

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Hlavní autoři: Winter, Jaclyn M., Chiou, Grace, Bothwell, Ian R., Xu, Wei, Garg, Neil K., Luo, Minkui, Tang, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779521/
https://ncbi.nlm.nih.gov/pubmed/23837609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol401723h
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