Large-Scale, Protection-Free Synthesis of Se-Adenosyl-l-selenomethionine Analogues and Their Application as Cofactor Surrogates of Methyltransferases

[Image: see text] S-Adenosyl-l-methionine (SAM) analogues have previously demonstrated their utility as chemical reporters of methyltransferases. Here we describe the facile, large-scale synthesis of Se-alkyl Se-adenosyl-l-selenomethionine (SeAM) analogues and their precursor, Se-adenosyl-l-selenoho...

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Main Authors: Bothwell, Ian R., Luo, Minkui
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059250/
https://ncbi.nlm.nih.gov/pubmed/24852128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol501169y
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