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Labeling Substrates of Protein Arginine Methyltransferase with Engineered Enzymes and Matched S-Adenosyl-L-methionine Analogues

Elucidating physiological and pathogenic functions of protein methyltransferases (PMTs) relies on knowing their substrate profiles. S-adenosyl-L-methionine (SAM) is the sole methyl-donor cofactor of PMTs. Recently, SAM analogues have emerged as novel small-molecule tools to label PMT substrates. Her...

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Detalhes bibliográficos
Main Authors: Wang, Rui, Zheng, Weihong, Yu, Haiqiang, Deng, Haiteng, Luo, Minkui
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104021/
https://ncbi.nlm.nih.gov/pubmed/21539310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2006719
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