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Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain
[Image: see text] A strategy for introducing structural diversity into polyketides by exploiting the promiscuity of an in-line methyltransferase domain in a multidomain polyketide synthase in reported. In vitro investigations using the highly-reducing fungal polyketide synthase CazF revealed that it...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779521/ https://ncbi.nlm.nih.gov/pubmed/23837609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol401723h |
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