SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice

Increased de novo lipogenesis is one of the major metabolic events in cancer. In human hepatocellular carcinoma (HCC), de novo lipogenesis has been found to be increased and associated with the activation of AKT/mTOR signaling. In mice, overexpression of an activated form of AKT results in increased...

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Bibliografske podrobnosti
Main Authors: Li, Lei, Wang, Chunmei, Calvisi, Diego F., Evert, Matthias, Pilo, Maria G., Jiang, Lijie, Yuneva, Mariia, Chen, Xin
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777889/
https://ncbi.nlm.nih.gov/pubmed/24069385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075104
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