Deletion of the Vaccinia Virus Gene A46R, Encoding for an Inhibitor of TLR Signalling, Is an Effective Approach to Enhance the Immunogenicity in Mice of the HIV/AIDS Vaccine Candidate NYVAC-C

Viruses have developed strategies to counteract signalling through Toll-like receptors (TLRs) that are involved in the detection of viruses and induction of proinflammatory cytokines and IFNs. Vaccinia virus (VACV) encodes A46 protein which disrupts TLR signalling by interfering with TLR: adaptor in...

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Main Authors: Perdiguero, Beatriz, Gómez, Carmen Elena, Di Pilato, Mauro, Sorzano, Carlos Oscar S., Delaloye, Julie, Roger, Thierry, Calandra, Thierry, Pantaleo, Giuseppe, Esteban, Mariano
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775734/
https://ncbi.nlm.nih.gov/pubmed/24069354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074831
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