Deletion of the Vaccinia Virus Gene A46R, Encoding for an Inhibitor of TLR Signalling, Is an Effective Approach to Enhance the Immunogenicity in Mice of the HIV/AIDS Vaccine Candidate NYVAC-C

Viruses have developed strategies to counteract signalling through Toll-like receptors (TLRs) that are involved in the detection of viruses and induction of proinflammatory cytokines and IFNs. Vaccinia virus (VACV) encodes A46 protein which disrupts TLR signalling by interfering with TLR: adaptor in...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Perdiguero, Beatriz, Gómez, Carmen Elena, Di Pilato, Mauro, Sorzano, Carlos Oscar S., Delaloye, Julie, Roger, Thierry, Calandra, Thierry, Pantaleo, Giuseppe, Esteban, Mariano
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2013
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775734/
https://ncbi.nlm.nih.gov/pubmed/24069354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074831
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