Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

Modified vaccinia virus Ankara (MVA) is an attenuated double-stranded DNA poxvirus currently developed as a vaccine vector against HIV/AIDS. Profiling of the innate immune responses induced by MVA is essential for the design of vaccine vectors and for anticipating potential adverse interactions betw...

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Detalhes bibliográficos
Main Authors: Delaloye, Julie, Roger, Thierry, Steiner-Tardivel, Quynh-Giao, Le Roy, Didier, Knaup Reymond, Marlies, Akira, Shizuo, Petrilli, Virginie, Gomez, Carmen E., Perdiguero, Beatriz, Tschopp, Jürg, Pantaleo, Giuseppe, Esteban, Mariano, Calandra, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691956/
https://ncbi.nlm.nih.gov/pubmed/19543380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000480
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