Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

BACKGROUND: Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a crystal called hemozoin that is generated by detoxification of heme after hemoglobin degrada...

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Bibliographische Detailangaben
Hauptverfasser: Dostert, Catherine, Guarda, Greta, Romero, Jackeline F., Menu, Philippe, Gross, Olaf, Tardivel, Aubry, Suva, Mario-Luca, Stehle, Jean-Christophe, Kopf, Manfred, Stamenkovic, Ivan, Corradin, Giampietro, Tschopp, Jurg
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714977/
https://ncbi.nlm.nih.gov/pubmed/19652710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006510
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