Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

The intraerythrocytic parasite Plasmodium—the causative agent of malaria—produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis. Hz is rapidly ingested by phagocytes and induces the production of seve...

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Detalhes bibliográficos
Main Authors: Tiemi Shio, Marina, Eisenbarth, Stephanie C., Savaria, Myriam, Vinet, Adrien F., Bellemare, Marie-Josée, Harder, Kenneth W., Sutterwala, Fayyaz S., Bohle, D. Scott, Descoteaux, Albert, Flavell, Richard A., Olivier, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722371/
https://ncbi.nlm.nih.gov/pubmed/19696895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000559
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