Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice

Poxviruses encode multiple inhibitors of the interferon (IFN) system, acting at different levels and blocking the induction of host defense mechanisms. Two viral gene products, B19 and B8, have been shown to act as decoy receptors of type I and type II IFNs, blocking the binding of IFN to its recept...

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Detalhes bibliográficos
Main Authors: Gómez, Carmen Elena, Perdiguero, Beatriz, Nájera, Jose Luis, Sorzano, Carlos Oscar S., Jiménez, Victoria, González-Sanz, Rubén, Esteban, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347383/
https://ncbi.nlm.nih.gov/pubmed/22419805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06684-11
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