High, Broad, Polyfunctional, and Durable T Cell Immune Responses Induced in Mice by a Novel Hepatitis C Virus (HCV) Vaccine Candidate (MVA-HCV) Based on Modified Vaccinia Virus Ankara Expressing the Nearly Full-Length HCV Genome

A major goal in the control of hepatitis C infection is the development of a vaccine. Here, we have developed a novel HCV vaccine candidate based on the highly attenuated poxvirus vector MVA (referred to as MVA-HCV) expressing the nearly full-length (7.9-kbp) HCV sequence, with the aim to target alm...

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Detalhes bibliográficos
Main Authors: Gómez, Carmen E., Perdiguero, Beatriz, Cepeda, María Victoria, Mingorance, Lidia, García-Arriaza, Juan, Vandermeeren, Andrea, Sorzano, Carlos Óscar S., Esteban, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700320/
https://ncbi.nlm.nih.gov/pubmed/23596307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03246-12
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