Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) affecting 71 million people worldwide with no licensed vaccines that prevent infection. Here, we have generated four novel alphavirus-based DNA-launched self-amplifying RNA replicon (DREP) vaccines expressing either structural core...

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Bibliographic Details
Published in:J Virol
Main Authors: Marín, María Q., Pérez, Patricia, Ljungberg, Karl, Sorzano, Carlos Óscar S., Gómez, Carmen E., Liljeström, Peter, Esteban, Mariano, García-Arriaza, Juan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430543/
https://ncbi.nlm.nih.gov/pubmed/30674625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00055-19
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