Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens

A modified vaccinia virus Ankara poxvirus vector expressing the HIV-1 Env, Gag, Pol, and Nef antigens from clade B (MVA-B) is currently being tested in clinical trials. To improve its immunogenicity, we have generated and characterized the immune profile of MVA-B containing a deletion of the vaccini...

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Bibliographic Details
Main Authors: García-Arriaza, Juan, Gómez, Carmen E., Sorzano, Carlos Óscar S., Esteban, Mariano
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957918/
https://ncbi.nlm.nih.gov/pubmed/24390336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02723-13
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