Deletion of Specific Immune-Modulatory Genes from Modified Vaccinia Virus Ankara-Based HIV Vaccines Engenders Improved Immunogenicity in Rhesus Macaques

Modified vaccinia virus Ankara (MVA) is a safe, attenuated orthopoxvirus that is being developed as a vaccine vector but has demonstrated limited immunogenicity in several early-phase clinical trials. Our objective was to rationally improve the immunogenicity of MVA-based HIV/AIDS vaccines via the t...

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Autors principals: Garber, David A., O'Mara, Leigh A., Gangadhara, Sailaja, McQuoid, Monica, Zhang, Xiugen, Zheng, Rui, Gill, Kiran, Verma, Meena, Yu, Tianwei, Johnson, Brent, Li, Bing, Derdeyn, Cynthia A., Ibegbu, Chris, Altman, John D., Hunter, Eric, Feinberg, Mark B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497691/
https://ncbi.nlm.nih.gov/pubmed/22973033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00246-12
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