Deletion of Specific Immune-Modulatory Genes from Modified Vaccinia Virus Ankara-Based HIV Vaccines Engenders Improved Immunogenicity in Rhesus Macaques

Modified vaccinia virus Ankara (MVA) is a safe, attenuated orthopoxvirus that is being developed as a vaccine vector but has demonstrated limited immunogenicity in several early-phase clinical trials. Our objective was to rationally improve the immunogenicity of MVA-based HIV/AIDS vaccines via the t...

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Autori principali: Garber, David A., O'Mara, Leigh A., Gangadhara, Sailaja, McQuoid, Monica, Zhang, Xiugen, Zheng, Rui, Gill, Kiran, Verma, Meena, Yu, Tianwei, Johnson, Brent, Li, Bing, Derdeyn, Cynthia A., Ibegbu, Chris, Altman, John D., Hunter, Eric, Feinberg, Mark B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497691/
https://ncbi.nlm.nih.gov/pubmed/22973033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00246-12
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