Introduction of the Six Major Genomic Deletions of Modified Vaccinia Virus Ankara (MVA) into the Parental Vaccinia Virus Is Not Sufficient To Reproduce an MVA-Like Phenotype in Cell Culture and in Mice

Modified vaccinia virus Ankara (MVA) has a highly restricted host range in cell culture and is apathogenic in vivo. MVA was derived from the parental chorioallantois vaccinia virus Ankara (CVA) by more than 570 passages in chicken embryo fibroblast (CEF) cells. During CEF cell passaging, six major d...

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Bibliographische Detailangaben
Hauptverfasser: Meisinger-Henschel, Christine, Späth, Michaela, Lukassen, Susanne, Wolferstätter, Michael, Kachelriess, Heike, Baur, Karen, Dirmeier, Ulrike, Wagner, Markus, Chaplin, Paul, Suter, Mark, Hausmann, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937755/
https://ncbi.nlm.nih.gov/pubmed/20668072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00756-10
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