The Vaccinia Virus O1 Protein Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase 1/2 and Promotes Viral Virulence

Sustained activation of the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway in infected cells has been shown to be crucial for full replication efficiency of orthopoxviruses in cell culture. In infected cells, this pathway is mainly activated by the vaccinia virus growth factor (VGF), an...

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Main Authors: Schweneker, Marc, Lukassen, Susanne, Späth, Michaela, Wolferstätter, Michael, Babel, Eveline, Brinkmann, Kay, Wielert, Ursula, Chaplin, Paul, Suter, Mark, Hausmann, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302380/
https://ncbi.nlm.nih.gov/pubmed/22171261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06166-11
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