Immediate-Early Expression of a Recombinant Antigen by Modified Vaccinia Virus Ankara Breaks the Immunodominance of Strong Vector-Specific B8R Antigen in Acute and Memory CD8 T-Cell Responses

Efficient T-cell responses against recombinant antigens expressed by vaccinia virus vectors require expression of these antigens in the early phase of the virus replication cycle. The kinetics of recombinant gene expression in poxviruses are largely determined by the promoter chosen. We used the hig...

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Detalhes bibliográficos
Main Authors: Baur, Karen, Brinkmann, Kay, Schweneker, Marc, Pätzold, Juliane, Meisinger-Henschel, Christine, Hermann, Judith, Steigerwald, Robin, Chaplin, Paul, Suter, Mark, Hausmann, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919044/
https://ncbi.nlm.nih.gov/pubmed/20538860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00604-10
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