Interleukin-1- and Type I Interferon-Dependent Enhanced Immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef Vaccine Vector with Dual Deletions of Type I and Type II Interferon-Binding Proteins

NYVAC, a highly attenuated, replication-restricted poxvirus, is a safe and immunogenic vaccine vector. Deletion of immune evasion genes from the poxvirus genome is an attractive strategy for improving the immunogenic properties of poxviruses. Using systems biology approaches, we describe herein the...

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Veröffentlicht in:J Virol
Hauptverfasser: Delaloye, Julie, Filali-Mouhim, Abdelali, Cameron, Mark J., Haddad, Elias K., Harari, Alexandre, Goulet, Jean-Pierre, Gomez, Carmen E., Perdiguero, Beatriz, Esteban, Mariano, Pantaleo, Giuseppe, Roger, Thierry, Sékaly, Rafick-Pierre, Calandra, Thierry
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403427/
https://ncbi.nlm.nih.gov/pubmed/25609807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03061-14
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