Interleukin-1- and Type I Interferon-Dependent Enhanced Immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef Vaccine Vector with Dual Deletions of Type I and Type II Interferon-Binding Proteins

NYVAC, a highly attenuated, replication-restricted poxvirus, is a safe and immunogenic vaccine vector. Deletion of immune evasion genes from the poxvirus genome is an attractive strategy for improving the immunogenic properties of poxviruses. Using systems biology approaches, we describe herein the...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Delaloye, Julie, Filali-Mouhim, Abdelali, Cameron, Mark J., Haddad, Elias K., Harari, Alexandre, Goulet, Jean-Pierre, Gomez, Carmen E., Perdiguero, Beatriz, Esteban, Mariano, Pantaleo, Giuseppe, Roger, Thierry, Sékaly, Rafick-Pierre, Calandra, Thierry
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403427/
https://ncbi.nlm.nih.gov/pubmed/25609807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03061-14
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