Mutagenic and Cytotoxic Properties of Oxidation Products of 5-Methylcytosine Revealed by Next-Generation Sequencing

5-methylcytosine (5-mC) can be sequentially oxidized to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-foC), and finally to 5-carboxylcytosine (5-caC), which is thought to function in active DNA cytosine demethylation in mammals. Although the roles of 5-mC in epigenetic regulation of gene expr...

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Detalhes bibliográficos
Main Authors: Xing, Xi-Wen, Liu, Yu-Li, Vargas, Mario, Wang, Yinsheng, Feng, Yu-Qi, Zhou, Xiang, Yuan, Bi-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774748/
https://ncbi.nlm.nih.gov/pubmed/24066027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072993
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