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Mutagenic and Cytotoxic Properties of 6-Thioguanine, S(6)-Methylthioguanine, and Guanine-S(6)-sulfonic Acid
Thiopurine drugs, including 6-thioguanine ((S)G), 6-mercaptopurine, and azathioprine, are widely employed anticancer agents and immunosuppressants. The formation of (S)G nucleotides from the thiopurine prodrugs and their subsequent incorporation into nucleic acids are important for the drugs to exer...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259751/ https://ncbi.nlm.nih.gov/pubmed/18591241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804047200 |
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