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LC-MS/MS Coupled with Stable Isotope Dilution Method for the Quantification of 6-Thioguanine and S(6)-Methylthioguanine in Genomic DNA of Human Cancer Cells Treated with 6-Thioguanine
Thiopurines, including mercaptopurine (MP), 6-thioguanine ((S)G) and azathioprine, are widely used for the treatment of many human diseases including acute lymphoblastic leukemia (ALL). To exert their cytotoxic effect, these prodrugs need to be metabolically activated to (S)G nucleotides and incorpo...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922690/ https://ncbi.nlm.nih.gov/pubmed/20550170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac1008628 |
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