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Effects of 6-Thioguanine and S(6)-Methylthioguanine on Transcription in Vitro and in Human Cells

Thiopurine drugs are extensively used as chemotherapeutic agents in clinical practice, even though there is concern about the risk of therapy-related cancers. It has been previously suggested that the cytotoxicity of thiopurine drugs involves their metabolic activation, the resultant generation of 6...

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Detalhes bibliográficos
Main Authors: You, Changjun, Dai, Xiaoxia, Yuan, Bifeng, Wang, Yinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510796/
https://ncbi.nlm.nih.gov/pubmed/23076150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.418681
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