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6-Thioguanine and S(6)-Methylthioguanine Are Mutagenic in Human Cells
Thiopurines are effective immunosuppressants and anti-cancer agents. However, the long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer. To date, the specific mechanism(s) underlying the carcinogenicity associated with thiopurine treat...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010245/ https://ncbi.nlm.nih.gov/pubmed/20806951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100214b |
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