ロード中...
Rational optimization of drug-target residence time: Insights from inhibitor binding to the S. aureus FabI enzyme-product complex
Drug-target kinetics has recently emerged as an especially important facet of the drug discovery process. In particular, prolonged drug-target residence times may confer enhanced efficacy and selectivity in the open in vivo system. However, the lack of accurate kinetic and structural data for series...
保存先:
| 主要な著者: | , , , , , , , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774598/ https://ncbi.nlm.nih.gov/pubmed/23697754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400413c |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|