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Rational optimization of drug-target residence time: Insights from inhibitor binding to the S. aureus FabI enzyme-product complex
Drug-target kinetics has recently emerged as an especially important facet of the drug discovery process. In particular, prolonged drug-target residence times may confer enhanced efficacy and selectivity in the open in vivo system. However, the lack of accurate kinetic and structural data for series...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774598/ https://ncbi.nlm.nih.gov/pubmed/23697754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400413c |
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