Rational optimization of drug-target residence time: Insights from inhibitor binding to the S. aureus FabI enzyme-product complex

Drug-target kinetics has recently emerged as an especially important facet of the drug discovery process. In particular, prolonged drug-target residence times may confer enhanced efficacy and selectivity in the open in vivo system. However, the lack of accurate kinetic and structural data for series...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chang, Andrew, Schiebel, Johannes, Yu, Weixuan, Bommineni, Gopal R., Pan, Pan, Baxter, Michael V., Khanna, Avinash, Sotriffer, Christoph A., Kisker, Caroline, Tonge, Peter J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774598/
https://ncbi.nlm.nih.gov/pubmed/23697754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400413c
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