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Insights into Okazaki Fragment Synthesis by the T4 Replisome: THE FATE OF LAGGING-STRAND HOLOENZYME COMPONENTS AND THEIR INFLUENCE ON OKAZAKI FRAGMENT SIZE

In this study, we employed a circular replication substrate with a low priming site frequency (1 site/1.1 kb) to quantitatively examine the size distribution and formation pattern of Okazaki fragments. Replication reactions by the T4 replisome on this substrate yielded a patterned series of Okazaki...

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Bibliografiske detaljer
Main Authors: Chen, Danqi, Yue, Hongjun, Spiering, Michelle M., Benkovic, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774352/
https://ncbi.nlm.nih.gov/pubmed/23729670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.485961
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