Components of the Secondary Pathway Stimulate the Primary Pathway of Eukaryotic Okazaki Fragment Processing

Reconstitution of eukaryotic Okazaki fragment processing implicates both one- and two-nuclease pathways for processing flap intermediates. In most cases, FEN1 (flap endonuclease 1) is able to efficiently cleave short flaps as they form. However, flaps escaping cleavage bind replication protein A (RP...

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Bibliographic Details
Main Authors: Henry, Ryan A., Balakrishnan, Lata, Ying-Lin, Stefanie Tan, Campbell, Judith L., Bambara, Robert A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937875/
https://ncbi.nlm.nih.gov/pubmed/20628185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131870
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