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Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement Synthesis
Okazaki fragment maturation to produce continuous lagging strands in eukaryotic cells requires precise coordination of strand displacement synthesis by DNA polymerase δ (Pol δ) with 5·-flap cutting by FEN1(RAD27) endonuclease. Excessive strand displacement is normally prevented by the 3·-exonuclease...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2590699/ https://ncbi.nlm.nih.gov/pubmed/18927077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806668200 |
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