Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement Synthesis

Okazaki fragment maturation to produce continuous lagging strands in eukaryotic cells requires precise coordination of strand displacement synthesis by DNA polymerase δ (Pol δ) with 5·-flap cutting by FEN1(RAD27) endonuclease. Excessive strand displacement is normally prevented by the 3·-exonuclease...

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Hlavní autoři: Stith, Carrie M., Sterling, Joan, Resnick, Michael A., Gordenin, Dmitry A., Burgers, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590699/
https://ncbi.nlm.nih.gov/pubmed/18927077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806668200
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