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Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

In eukaryotes, DNA polymerase δ (pol δ) is responsible for replicating the lagging strand template and anchors to the proliferating cell nuclear antigen (PCNA) sliding clamp to form a holoenzyme. The stability of this complex is integral to every aspect of lagging strand replication. Most of our und...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Hedglin, Mark, Pandey, Binod, Benkovic, Stephen J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822616/
https://ncbi.nlm.nih.gov/pubmed/26976599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523653113
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