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Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis
In eukaryotes, DNA polymerase δ (pol δ) is responsible for replicating the lagging strand template and anchors to the proliferating cell nuclear antigen (PCNA) sliding clamp to form a holoenzyme. The stability of this complex is integral to every aspect of lagging strand replication. Most of our und...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822616/ https://ncbi.nlm.nih.gov/pubmed/26976599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523653113 |
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