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Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours Around the Same Obstacle

During S-phase, minor DNA damage may be overcome by DNA damage tolerance (DDT) pathways that bypass such obstacles, postponing repair of the offending damage to complete the cell cycle and maintain cell survival. In translesion DNA synthesis (TLS), specialized DNA polymerases replicate the damaged D...

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Détails bibliographiques
Publié dans:Chem Rev
Auteurs principaux: Hedglin, Mark, Benkovic, Stephen J.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662946/
https://ncbi.nlm.nih.gov/pubmed/28497687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.7b00046
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