Subtype-specific Residues Involved in Ligand Activation of the Endothelial Differentiation Gene Family Lysophosphatidic Acid Receptors

Lysophosphatidic acid (LPA) is a ligand for three endothelial differentiation gene family G protein-coupled receptors, LPA(1–3). We performed computational modeling-guided mutagenesis of conserved residues in transmembrane domains 3, 4, 5, and 7 of LPA(1–3) predicted to interact with the glycerophos...

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Autori principali: Valentine, William J., Fells, James I., Perygin, Donna H., Mujahid, Sana, Yokoyama, Kazuaki, Fujiwara, Yuko, Tsukahara, Ryoko, Van Brocklyn, James R., Parrill, Abby L., Tigyi, Gabor
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774115/
https://ncbi.nlm.nih.gov/pubmed/18316373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708847200
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