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Kinetic and Structural Characterization of Dihydrofolate Reductase from Streptococcus pneumoniae

Drug resistance associated with dihydrofolate reductase (DHFR) has emerged as a critical issue in the treatment of bacterial infections. In our efforts to understand the mechanism of a drug-resistant dihydrofolate reductase (DHFR) from a pathogenic bacterial source, we report the first kinetic chara...

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Библиографические подробности
Главные авторы: Lee, Jeeyeon, Yennawar, Neela H., Gam, Jongsik, Benkovic, Stephen J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773979/
https://ncbi.nlm.nih.gov/pubmed/19950924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901614m
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