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Kinetic and Chemical Mechanism of the Dihydrofolate Reductase from Mycobacterium tuberculosis
Dihydrofolate reductase from Mycobacterium tuberculosis catalyzes the NAD(P)H dependent reduction of dihydrofolate, yielding NAD(P)(+) and tetrahydrofolate, the primary one carbon unit carrier in biology. Tetrahydrofolate needs to be recycled so that reactions involved in dTMP synthesis and purine m...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3074011/ https://ncbi.nlm.nih.gov/pubmed/21138249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1016843 |
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