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Kinetic and Chemical Mechanism of the Dihydrofolate Reductase from Mycobacterium tuberculosis
Dihydrofolate reductase from Mycobacterium tuberculosis catalyzes the NAD(P)H dependent reduction of dihydrofolate, yielding NAD(P)(+) and tetrahydrofolate, the primary one carbon unit carrier in biology. Tetrahydrofolate needs to be recycled so that reactions involved in dTMP synthesis and purine m...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3074011/ https://ncbi.nlm.nih.gov/pubmed/21138249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1016843 |
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