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Kinetic and Chemical Mechanism of α–Isopropylmalate Synthase from Mycobacterium tuberculosis
Mycobacterium tuberculosis α–isopropylmalate synthase (MtIPMS) catalyzes the condensation of AcCoA with α–ketoisovalerate (α–KIV) and the subsequent hydrolysis of α–isopropylmalyl-CoA to generate the products CoA and α–isopropylmalate (α–IPM). This is the first committed step in L–leucine biosynthes...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2507874/ https://ncbi.nlm.nih.gov/pubmed/16846242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0606602 |
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