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Kinetic Evidence for Inter-Domain Communication in the Allosteric Regulation of α-Isopropylmalate Synthase from M. tuberculosis

The enzyme α-isopropylmalate synthase from Mycobacterium tuberculosis (MtIPMS) has been identified as a possible target for design of new anti-tubercular therapeutics. Recently it was shown that MtIPMS is subject to slow-onset, feedback inhibition by L-leucine, the first instance of an allosteric re...

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Detalhes bibliográficos
Main Authors: de Carvalho, Luiz Pedro S., Frantom, Patrick A., Argyrou, Argyrides, Blanchard, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724842/
https://ncbi.nlm.nih.gov/pubmed/19166329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801707t
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