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Kinetic Evidence for Inter-Domain Communication in the Allosteric Regulation of α-Isopropylmalate Synthase from M. tuberculosis
The enzyme α-isopropylmalate synthase from Mycobacterium tuberculosis (MtIPMS) has been identified as a possible target for design of new anti-tubercular therapeutics. Recently it was shown that MtIPMS is subject to slow-onset, feedback inhibition by L-leucine, the first instance of an allosteric re...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724842/ https://ncbi.nlm.nih.gov/pubmed/19166329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801707t |
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