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Kinetic and Structural Characterization of Dihydrofolate Reductase from Streptococcus pneumoniae
Drug resistance associated with dihydrofolate reductase (DHFR) has emerged as a critical issue in the treatment of bacterial infections. In our efforts to understand the mechanism of a drug-resistant dihydrofolate reductase (DHFR) from a pathogenic bacterial source, we report the first kinetic chara...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773979/ https://ncbi.nlm.nih.gov/pubmed/19950924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901614m |
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